Environmental pollution with antimicrobial agents from bulk drug manufacturing industries in Hyderabad, South India

High antibiotic and antifungal concentrations in wastewater from anti-infective drug production may exert selection pressure for multidrug-resistant (MDR) pathogens. This study investigated the environmental presence of active pharmaceutical ingredients and their association with MDR bacteria in Hyderabad, South India, a major production area for the global bulk drug market.
Water samples were collected from the direct environment of bulk drug manufacturing facilities. Samples were analyzed for 25 anti-infective pharmaceuticals.   All environmental specimens from 28 different sampling   sites   were   contaminated   with   antimicrobials.

High  concentrations  of  moxifloxacin,  voriconazole,  and fluconazole  as  well  as  increased  concentrations  of  eight  other antibiotics  were  found  in  sewers.  Corresponding analyses  revealed  an  extensive  presence  of  enterobacteria.   Insufficient  wastewater  management  by  bulk   drug  manufacturing  facilities  leads  to  unprecedented  contamination  of  water  resources  with  antimicrobial  pharmaceuticals,  which  seems  to  be  associated  with  the  selection  and dissemination of pathogens.  The development and global spread of antimicrobial resistance present a major challenge for pharmaceutical producers and regulatory agencies.

Citation: Lübbert, C., Baars, C., Dayakar, A. et al. Environmental pollution with antimicrobial agents from bulk drug manufacturing industries in Hyderabad, South India, is associated with dissemination of extended-spectrum beta-lactamase and carbapenemase-producing pathogens Infection (2017). Published online on April 26,2017.